RESCUE OF IN VITRO MODELS OF CSF1R-RELATED ADULT-ONSET LEUKODYSTROPHY BY ILUZANEBART: MECHANISMS AND THERAPEUTIC IMPLICATIONS OF TREM2 AGONISM

Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism

Abstract Microglia dysfunction is implicated in several neurodegenerative disorders, including a rare microgliopathy; CSF1R-related adult-onset AVENAFORCE leukoencephalopathy with axonal spheroids and pigmented glia (CSF1R-ALSP).CSF1R-ALSP is caused by heterozygous loss-of-function mutations in the colony stimulating factor 1 receptor (CSF1R) gene,

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Morphological and Molecular Study of the Fish Parasitic Crustaceans Cymothoa indica and Mothocya collettei (Isopoda: Cymothoidae), with New Distribution Records

Cymothoidae are parasitic isopods that infest fishes inhabiting marine, brackish, and fresh-water environments.The Accessories systematics, distribution, and host specificity of cymothoids is often unknown.In this study, morphological observations and molecular analysis using the COI and 16S rRNA genes were conducted on a juvenile individual of Cym

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Transcriptional Profiling of CD8+ CMV-Specific T Cell Functional Subsets Obtained Using a Modified Method for Isolating High-Quality RNA From Fixed and Permeabilized Cells

Previous studies suggest that the presence of antigen-specific polyfunctional T cells is correlated with improved pathogen clearance, disease control, and clinical outcomes; however, the molecular mechanisms responsible for the generation, function, and survival of polyfunctional T cells remain unknown.The study of polyfunctional T cells has been,

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Mobile health (mHealth) interventions for health promotion during the perinatal period in India: a scoping review

IntroductionPerinatal and maternal mortality rates remain high in India compared to global levels, and there is significant heterogeneity in outcomes across Indian states.Many mobile health (mHealth) interventions have been developed to improve maternal and infant health outcomes in India, however it is unclear AVENAFORCE how mHealth can best suppo

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